Sperm acrosome reaction: its site and role in fertilization†
نویسندگان
چکیده
منابع مشابه
Site of the mammalian sperm physiological acrosome reaction.
I n mammals and the many other animals in which fertilization involves the establishment of a penetration path through the egg coat, at the apex of the sperm head lies the acrosome— a membrane-limited organelle that houses a complex of enzymes. For fertilization to occur, spermatozoa must first undergo the acrosome reaction (AR), which involves point fusions between the outer acrosomal and over...
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Capacitation is an important physiological pre-requisite before the sperm cell can acrosome react and fertilize the oocyte. Recent reports from several laboratories have amply documented that the protein phosphorylation especially at tyrosine residues is one of the most important events that occur during capacitation. In this article, we have reviewed the data from our and other laboratories, a...
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F or successful mammalian fertilization, sperm penetrate the outer investments of female gametes in the ampulla of the oviduct and fuse with the egg plasma membrane. The “fertilizing” sperm traverse the cumulus mass surrounding ovulated eggs, bind temporarily, and then penetrate through the zona pellucida, a structured extracellular glycomatrix, to enter into the perivitelline space (Fig. 1A). ...
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To bind and fertilize the egg, the spermatozoon should undergo few biochemical and motility changes in the female reproductive tract collectively called capacitation. The capacitated spermatozoon binds to the egg zona pellucida, and then undergoes the acrosome reaction (AR), which allows its penetration into the egg. The mechanisms regulating sperm capacitation and the AR are not completely und...
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Binding to the zona pellucida of an egg stimulates the spermatozoon to undergo the acrosome reaction, a process that enables it to penetrate the egg. Before this binding, the spermatozoon undergoes a series of biochemical transformations in the female reproductive tract, collectively called capacitation. Only capacitated spermatozoa can bind to the zona pellucida and undergo the acrosome reacti...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2018
ISSN: 0006-3363,1529-7268
DOI: 10.1093/biolre/ioy045